BoneVigor^TM (Gu Zhi Shu Song Pian, Gu Zhi Shu Song Wan, 骨质疏松丸), is a Chinese herbal medicine formulated to support a healthy bone function.^† The Chinese medicine may help increase bone strength and stop bone loss commonly seen in women after menopause and men at old ages.^†

What does it do?
Osteoporosis is a bone disease marked by the reduced bone mass density (BMD) and the degenerative bone microstructure. Osteoporosis itself does not necessarily show any specific symptom but it renders the body at a much bigger risk of bone fractures (e.g., hip, wrist, spine) due to the poor bone structure. A common sign of osteoporosis is curvature or shortened stature in older people, or even hunchback. Osteoporosis may also cause pain on the back and in the limbs.

Osteoporosis is the result of an imbalance between the opposite bone resorption and bone formation. In the body, bone undergoes a constant turnover in which osteoclast cells remove its mineralized matrix whereas osteoblast cells deposit the new bone matrix. As we age, bone resorption becomes more dominant over bone formation and thus leads to bone loss. For example, estrogen has a function in inhibiting bone resorption and lack of estrogen (e. g., as a result of menopause) thus increases the loss of bone matrix.

In traditional Chinese medicine (TCM), bones are governed by the kidneys, a primary source of essence of life and of the Yin and Yang energy. Thus, a strong kidney function provides ample nutrients that promote a robust formation of bones. When the kidney function is weakened, bone loss outpaces bone formation and causes osteoporosis. Consequently, strengthening the kidney function is considered to be a main principle in TCM to treat osteoporosis. Although it is to be interpreted by modern biomedical studies, Chinese herbal formulas that follow the principle have shown satisfactory results in stopping bone loss and increasing bone mass in clinical studies in China. BoneVigor is our signature formula that follows the principle for bone health.

• Bu Gu Zhi (Psoralea fruit) tonifies the kidneys, strengthens the Yang energy, reserves the essence. In studies of osteoporosis animal models, Psoralea extracts increase serum calcium levels and decrease urinary calcium excretion, reduce bone loss and lead to the gain in bone mineral density.¹ A compound isolated from Psoralea is further found to inhibit the formation of osteoclasts, the cells that resorb the bone matrix;²
• Gu Sui Bu (Drynaria) nourishes the kidneys and is well known among Chinese medicines for its property in promoting healing of bones after injury. In studies of osteoporosis animal models, Drynaria extracts can significantly increase bone mineral density and promotes bone-forming osteoblast differentiation and mineralization;^3,4
• Du Zhong (Eucommia) is a popular tonic for both the liver and the kidneys. The Chinese herb is well recognized for strengthening bones and tendons and is commonly used for lower back pain and joint pain. Extracts prepared from Eucommia have been shown to prevent bone loss from postmenopausal animals;⁵
• Xu Duan (Dipsacus) is another Chinese herb that tonifies both the liver and the kidneys and strengthens the bones. Its extracts are also found to promote bone formation in experimental animals;
• Tu Si Zi (Cuscuta seed) invigorates the kidneys and nourishes the liver and the bone marrow. Cuscuta seed extracts are shown to promote differentiation and mineralization of human osteoblast cells;⁶
• Shu Di (Rehmannia root) nourishes the Yin energy and tonifies the blood;
• Bai Shao (White Paeony root) nourishes the blood, harmonizes the liver and relieves the pain;
• Dan Shen (Salvia) promotes blood circulation and removes blood stasis. Blood stasis is often associated with osteoporosis in the pattern diagnosis of TCM. Indeed, Dan Shen extracts are able to prevent bone loss caused by ovary removal in animal models;⁷
• Mu Li (Oyster) nourishes the Yin energy and calms the liver. It is a rich source of calcium, phosphate, and zinc and supplements the calcium needed in bone formation. Oyster powders can enhance proliferation and differentiation of osteoblast cells in cultured cells and thus prevent bone loss;⁸
• Long Gu has properties similar to Mu Li;

*BoneVigor is made of 100% pure authentic Chinese herbs of highest qualities. Traditional preparation procedures are combined with modern pharmaceutical processes to extract the active ingredients from the herbs and to further concentrate them into pills or tablets. It is produced in the certified GMP facilities of Shanghai TongHanChun Herbs Factory (Guang Ci Tang) and is imported to USA in accordance with the FDA guidelines.

What is Available?
One top Chinese herbs brand:
Guang Ci Tang (learn more): 40 grams in 400 mg 100 tablets or 200 mg 200 pills per bottle.

How do I use it?
Take 5 to 7 pills or 3 to 4 tablets three times daily.

Use Discretion

Side Effects
BoneVigor has been safely used with few adverse effects when it is used as directed.

Cautious Notes
1. Consult your herbalist or physician before use if you are taking other medicines.
2. Keep out of reach of children.

References
1. Tsai MH et al., Psoralea corylifolia extract ameliorates experimental osteoporosis in ovariectomized rats. Am J Chin Med. 2007;35(4):669-80.
2. Park CK et al., Bavachalcone inhibits osteoclast differentiation through suppression of NFATc1 induction by RANKL. Biochem Pharmacol. 2008 Jun 1;75(11):2175-82.
3. Xie YM, Ju DH, Zhao JN Effect of osteopractic total flavone on bone mineral density and bone histomorphometry in ovariectomized rats. Zhongguo Zhong Yao Za Zhi. 2004 Apr;29(4):343-6.
4. Jeong JC et al., Drynariae Rhizoma promotes osteoblast differentiation and mineralization in MC3T3-E1 cells through regulation of bone morphogenetic protein-2, alkaline phosphatase, type I collagen and collagenase-1. Toxicol In Vitro. 2004 Dec;18(6):829-34.
5. Zhang R et al., Du-Zhong (Eucommia ulmoides Oliv.) cortex extract prevent OVX-induced osteoporosis in rats. Bone. 2008 Sep 16.
6. Yang HM et al., Cuscuta chinensis extract promotes osteoblast differentiation and mineralization in human osteoblast-like MG-63 cells. J Med Food. 2009 Feb;12(1):85-92.
7. Chae HJ et al., Prevention of bone loss in ovariectomized rats: the effect of Salvia miltiorrhiza extracts. Immunopharmacol Immunotoxicol. 2004 Feb;26(1):135-44.
8. Han SY et al., Ostreae Testa prevent ovariectomy-induced bone loss in mice by osteoblast activations. J Ethnopharmacol. 2007 Dec 3;114(3):400-5.

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