Scientists have inserted a worm gene into mice, and the
results of their efforts may one day transform steak and eggs into the
heart-healthiest meal you could eat.
Mammals can't convert omega-6 fatty acids into the healthier omega-3 version.
Even fish can't do it. Popular omega-3 sources such as salmon don't actually
produce the fat - they accumulate it from the algae they eat.
Omega-6 and Omega-3 are fatty acids that can be obtained only through food.
Both have many health benefits, but omega-3 has been shown to reduce
significantly the risk of heart attack and stroke. Nutritionists urge a balance
of both, but people generally consume more omega-6 because it is found in more
common foods, such as cereals, vegetable oils and whole-grain breads.
But now, researchers at Harvard University have engineered a roundworm gene
to convert omega-6 to omega-3 and have successfully transferred it into mice,
according to an article in this week's issue of the science journal
Nature.
Performing this feat of bio-engineering on animals such as cattle, pigs and
chickens could lead to meat, eggs and dairy products that are rich in omega-3
fatty acids.
The potential for meeting increased demand for omega-3 is huge, says lead
researcher Jing Xuan Kang. "This is a safer and more convenient way than relying
solely on fish oil."
The Harvard work demonstrates the potential of this technology to produce
healthier products, says Alison Van Eenennaam, an animal geneticist at the
University of California- Davis who in another project has engineered mice to
make omega-3 in their milk.
"Instead of eating fish, you could eat a hamburger and still have the
beneficial effects of eating fish," she says.
It may also be safer. Many fish that contain significant amounts of omega-3
are contaminated with toxins such as mercury and cancer-causing polychlorinated
biphenyls, because of polluted water.
Those pollutants are eaten by algae, which are eaten by small fish, which are
eaten by larger fish. The toxins accumulate at each stage, resulting in
sometimes high levels in the fish that people eat.
A non-fish source also would be environmentally friendly. Farmed fish are fed
meal made from ocean fish as a protein and to increase their omega-3 levels. It
takes from two to five pounds of ocean fish to produce one pound of farmed fish,
leading to overfishing.