Supports a positive mood.†
Contains 0.3% hypericin.
In the tablet form as used in the clinical
Made in USA in GMP facilites.
One bottle lasts for one month.
All specifications same as used in the clinical trials to reproduce the positive outcome.
May be as effective as Prozac yet with less side effect. †
300 mg standardized extract 90 tablets per bottle
|This product has been discontinued.
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St. John's Wort (Hypericum perforatum, 圣约翰草) is the most commonly
used herb in USA and in Europe to maintain a positive mood. It is prescribed in Germany 20 times
more often than Prozac for treatment of depression. Clinical research has shown that
standardized St. John’s Wort extract helps improve symptoms related to depression.†
(see latest clinical trial news)
It has few side effect. However, caution needs to be taken if you are taking other prescription
drugs because drug interactions have been noticed.
St. John's Wort Health Benefits
Many clinical trials have been conducted by researchers in USA and Europe
to evaluate the use of St. John's Wort as antidepressant. In a meta analysis of St. John's Wort clinical trials,
23 randomized, placebo or antidepressant drug controlled trials were identified, of which 20 trials were
further double blinded. The analysis revealed that all but two trials showed that St. John's Wort
is significantly superior to placebo and is as effective as antidepressants in the treatment of mild and moderate
In a subsequent, well publicized trial funded by NIH, however, St. John's Wort
was found no better than placebo.1 What the media failed to mention to the public was that in the same trial
sertraline, a standard antidepressant approved by FDA, was no better than placebo too, which means
even a known antidepressant did not work in the trial, suggesting the trial simply did not work and
does not actually tell anything about St. John's Wort. It is noteworthy that in the trial the patients
are all in major depressive disorder.2
It comes to 2005 when a new and well publicized trial was released. Here
251 patients with acute major depression were randomized to receive either a St. John's Wort standardized
extract, or popular antidepressant drug Prozac in a double blinded manner.3 Both St. John's Wort
and Prozac were used in their standard dose for 6 weeks. The results shows that St. John's Wort is at least
as effective as Prozac in the treatment of depression yet has less side effect.3
(see related news)
Research on St. John's Wort mostly uses standardized extracts made from
its dry flowers and stems. The standardized extracts are concentrated 5-7 times and typically
contains 0.3% hypericin, which is believed to be the active ingredient of St. John's Wort.
Sometimes St. John's Wort extracts are standardized to 2-4.5% hyperforin, which was suggested by some research
to be the active ingredient. Nevertheless, most research and clinical trials have used standardized
St. John's Wort extract at 0.3% hypericin.
Dose and Duration
In the St. John's Wort clinical trials, patients typically took 900 mg
standardized extract per day, divided in 3 times. In case the body is not responding, the dose
were often raised to 1800 mg. The trials commonly last for 6 to 8 week. 1-3
St. John's Wort Side Effects
Side effects are few in the St. John's Wort clinical trials and less common than
the antidepressant drugs such as Prozac.1-3 However, the following mild adverse
reactions were occasionally observed: upper abdominal pain, diarrhoea, dry mouth, nausea, fatigue, dizziness,
headache, sleep disorder and sweating.
St. John's Wort Drug Interaction
Numerous studies suggest that St. John's Wort may interact with other
prescription drugs to weeken their effects. Examples may include: anti-HIV drug indinavir, the
cyclosporine, anticoagulants like warfarin, anti-cancer drugs like irinotecan. So caution needs to be taken
if you are on other medications.
1. Linde K, Ramirez G, Mulrow CD, Pauls A, Weidenhammer W, Melchart D. St John's wort for
depression--an overview and meta-analysis of randomised clinical trials. BMJ. 1996 Aug 3;313(7052):253-8.
2. Hypericum Depression Trial Study Group. Effect of Hypericum perforatum (St John's wort)
in major depressive disorder: a randomized controlled trial.
JAMA. 2002 Apr 10;287(14):1807-14.
3. Szegedi A, Kohnen R, Dienel A, Kieser M.
Acute treatment of moderate to severe depression with hypericum extract
WS 5570 (St John's wort): randomised controlled double blind
non-inferiority trial versus paroxetine. BMJ. 2005 Mar 5;330(7490):503.
by X. Li, Ph. D.