Liu Wei Di Huang Wan (Liu Wei Di Huang Pian, YinVive^TM, Rehmannia six, Six Flavor Teapills, 六味地黄片) is among the most regarded ancient Chinese herbal formula. Today, it is most widely used to nourish Yin of the Yin-Yang principles and is the foundation for many other Chinese medicines. In traditional Chinese medicine, Yin is the womanish and negative principle of Yin-Yang whereas Yang is the mannish and positive principle. A robust interaction and balance of Yin-Yang forms the basis of a good health. A diminished Yin can be shown as sweat, low fever, dizziness, tinnitus, emission, soreness in the lower back etc. Yin weakness occurs with age, sexuality, or chronic diseases.

What does it do?
In Traditional Chinese Medicine (TCM), Liu Wei Di Huang Wan can replenish Yin due to the Yin insufficiency of the kidney. The kidney is the innate foundation of all organs with respect to the Yin-Yang principles, Qi essence etc. When the kidney is diminished functionally, many other organs show malfunctions. It is thus vitally important to maintain the kidney in a good state. This explains why many symptoms seemingly unrelated to the kidney may be relieved by restoring the kidney Yin-Yang.

While modern biomedical studies have yet to reveal the basis of the kidney Yin-Yang and how Liu Wei Di Huang Wan works, some researches have found that Liu Wei Di Huang Wan can increase the number of T lymphocytes and regulate the production of cytokines^{1, 2} and thus Liu Wei Di Huang Wan may adjust the immune function of our body. Liu Wei Di Huang Wan can also increase the production of sex hormones and of adrenal cortical hormones that have anti-inflammatory function in animal studies³. Moreover, Liu Wei Di Huang Wan can reduce blood sugar levels and increase the activity of superoxide dismutase (SOD) in the diabetes rat model⁴. SOD is a key enzyme for eliminating free radicals in the body and its enhanced function prolongs lifespan in animal studies.

Liu Wei Di Huang Wan is indicated in China Pharmacopoeia⁵ for Yin insufficiency of kidney; dizziness; tinnitus; weakness and soreness of the loins and the limbs; emission and sweating. Many published and unpublished human clinical studies have supported the use of Liu Wei Di Huang Wan in numerous conditions, some of which are highlighted below.

• Back pain due to the kidney Yin insufficency. Typically, you feel weakness and then soreness of the waist and legs. You may also feel dizziness, faint vision, tinnitus, tiredness, sweat or low fever. You start to forget things and do not sleep well. You feel you are sick but doctors cannot find any underlying cause. You are not alone and these are common problems for people especially professionals who spend hours daily in front of computers and who are getting older (e.g., over 40). (see low back pain for more info)

• Sexual performance. You feel you are not as hard as before and do not last as long as before. You feel sore waist the next day and it takes longer time for you to reinvigorate. (see sexual wellness for more info)

• Type II diabetes disease⁴. In recent years, Chinese doctors have found that Liu Wei Di Huang Wan is very effective in treating diabetes type II disease. In multiple controlled human clinical trials, Liu Wei Di Huang Wan is reported consistently effective in over 90% patients, of which most have their blood sugar levels returned to the normal. The treatment is at least as good as the standard treatment with western medicines. When Liu Wei Di Huang Wan is used together with western medicines, it further enhances the efficacy of the western medicines.

• Menopausal syndrome. In a human clinical trial, 23 women were treated with Liu Wei Di Huang Wan for 3 months, the symptoms of hectic fever, hot flash, sweating, palpitation, and insomnia were significantly improved in 39.1% patients. Additional 60.9% showed some improvement.

Professional comments
Guang Ci Tang: My Most Favorite Chinese Medicine

*Liu Wei Di Huang Wan is made of 100% pure authentic Chinese herbs of highest qualities. Traditional preparation procedures are combined with modern pharmaceutical processes to extract the active ingredients from the herbs and to further concentrate them into pills or tablets. It is produced in the certified GMP facilities of Shanghai TongHanChun Herbs Factory (Guang Ci Tang) and is imported to USA in accordance with the FDA guidelines.

What is Available?
One top Chinese herbs brand:
Guang Ci Tang (learn more): 40 grams in 200 mg 200 tablets or 200 mg 200 pills per bottle,

YinVive^TM by ActiveHerb is an enhanced form of Liu Wei Di Huang Wan with the inclusion of Polygoni Multiflori (He Shou Wu). It is more concentrated and more potent. It reduces the daily dose and lasts longer. It is made in USA. Learn More

How do I use it?
For Guang Ci Tang, 5 to 7 tablets or pills 2-3 times daily.

As the herbal formula is a mild tonic and acts slowly, results may only be noticeable after 1 month. It is suggested to take 4-6 bottles in full dose as the first regimen. The dose may then be reduced.

Use Discretion
Liu Wei Di Huang Wan is closely related to YanVive^TM in formulation and applications. YanVive is suitable for people who feel cold in the legs and whose face is pale, signs of Yang insufficiency. If no such signs are observed, Liu Wei Di Huang Wan is suggested for use.

Side Effects
Liu Wei Di Huang Wan has been safely used by millions of people with few adverse effects or contraindications. Suitable for a long term administration.

Cautious Notes
1. Do not use it if you are taking cold medicines.
2. Consult your herbalist or physician before use if you are pregnant.
3. Consult your herbalist or physician before use if you are taking other medicines.
4. If any adverse symptom occurs like lost appetite, discontinue use.
5. Keep out of reach of children.

References
1. Cai B, Jiang T. Study on preventive and curative effects of liu wei di huang tang on tumors. J Tradit Chin Med. 1994 Sep;14(3):207-11.
2. Shen JJ, Lin CJ, Huang JL, Hsieh KH, Kuo ML. The effect of liu-wei-di-huang wan on cytokine gene expression from human peripheral blood lymphocytes. Am J Chin Med. 2003;31(2):247-57.
3. Dharmananda S. Rehmannia. http://www.itmonline.org/arts/rehmann.htm.
4. Review of clinical applications of Liu Wei Di Huang Wan in treatment of diabetes and complications. Chinese J Current Traditional Western Medicine. A 1726-6424 (2003) 11-0976-02.
5. China Pharmacopoeia 2000.