|X. Li, Ph. D.
Master of Science in Medical Genetics, Shanghai Medical Unversity.
Doctor of Philosophy in Molecular Biology with Honor, University of Zurich.
After his Ph. D., he conducted research at Yale University, University of California at San Diego,
and the Scripps Research Institute. Over the years of his biomedical research, he has made several original important scientific
discoveries, which were published in prestigious scientific journals like Nature. His findings
have been featured twice in the famous textbook "Molecular Biology of the Gene" (5th ed. 2004) by
J. D. Watson, who discovered the DNA structure 50 years ago, and are being learnt by biomedical students in USA and around the
1. Graslund, T., Li, X. (joint first author), Magnenat, L., Popkov, M., Barbas III, C. F. (2005).
Exploring strategies for the design of artificial transcription factors: targeting sites proximal
to known regulatory regions for the induction of gamma-globin expression and the treatment of
sickle cell disease. J Biol Chem. 280, 3707-3714.
2. Segal DJ, Goncalves J, Eberhardy S, Swan CH, Torbett BE, Li X, Barbas CF
3rd. (2004). Attenuation of HIV-1 replication in primary human cells with a designed zinc
finger transcription factor.J Biol Chem. 279, 14509-19.
3. Xue, L., Li, X. and Noll, M. (2001). Encoding of multiple protein
functions of Paired in Drosophila development and their conservation
in the Gooseberry and Pax3 homologs. Development 128,
4. Veraksa, A., McGinnis, N., Li, X., Mohler, J. and McGinnis, W. (2000). Cap 'n' collar B cooperates
with a small Maf subunit to
specify pharyngeal development and suppress Deformed homeotic function in the Drosophila head.
Development 127, 4023-4037.
5. Li, X., Veraksa, A., and McGinnis, W.(1999). A sequence motif
distinct from Hox binding sites controls the specificity of a Hox response element. Development
6. Li, X. and McGinnis, W. (1999). Activity
regulation of Hox proteins, a mechanism for altering functional specificity in
development and evolution. Proc. Natl. Acad. Sci. U. S. A. 96, 6802-6807.
7. Li, X., Murre, C., and McGinnis, W.
(1999). Activity regulation of a Hox
protein and a role for the homeodomain in inhibiting transcriptional
activation. EMBO J. 18, 198-211.
8. Duman-Scheel, M., Li, X., Orlov, I., Noll, M., and Patel, N. H. (1997).
Genetic separation of the neural and cuticular patterning functions of gooseberry. Development
9. Li, X. and Noll, M. (1994).
Compatibility between enhancers and promoters determines the transcriptional
specificity of gooseberry and gooseberry neuro in the Drosophila
embryo. EMBO J. 13, 400-406.
10. Li, X. and Noll, M.(1994). Evolution of distinct developmental
functions of three Drosophila genes by acquisition of different cis-regulatory
regions. Nature 367, 83-87.
11. Li, X. and Noll, M. (1993). Role of the gooseberry gene in Drosophila embryos:
Maintenance of wingless expression by a wingless-gooseberry autoregulatory loop.
EMBO J. 12, 4499-4509.
12. Gutjahr, T., Patel, N.H., Li, X., Goodman, C.S., and Noll, M. (1993).Analysis of
the gooseberry locus in Drosophila embryos: gooseberry determines the cuticular pattern and activates
gooseberry neuro. Development 118, 21-31.
13. Li, X., Gutjahr, T., and Noll, M. (1993). Separable regulatory elements
mediate the establishment and maintenance of cell states by the Drosophila segment-polarity gene
gooseberry. EMBO J. 12, 1427-1436.